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Associate Professor · University of La Réunion

Professeur Chaker
El Kalamouni

Deputy Director, UMR PIMIT Lab

Antiviral Research · Tropical Infectious Diseases · Natural Product Chemistry

70+
Publications
1,146+
Citations
15+
Years Research
Professor Chaker El Kalamouni
ICAR 2022
Young Investigator Award — 1st Place
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A Life Dedicated to
Fighting Tropical Viruses

Professor Chaker El Kalamouni is an Associate Professor at the University of La Réunion and Deputy Director of the UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical) laboratory — a joint research unit of INSERM, CNRS, IRD, and the University of La Réunion.

His research sits at the intersection of virology, natural product chemistry, and tropical medicine. He focuses on the discovery and development of antiviral compounds from medicinal plants — particularly those endemic to the Mascarene Islands and the broader Indian Ocean region — against emerging arboviruses including Zika virus, Dengue virus, SARS-CoV-2, and Ross River virus.

Beyond the laboratory, Professor El Kalamouni is deeply committed to education and community engagement. He directs the Master 2 Biologie Santé program in Tropical Infectiology and Zoonoses, training the next generation of researchers in tropical health sciences.

Arbovirus Research Antiviral Natural Products Phytochemistry Host-Pathogen Interactions Zika Virus Dengue Virus SARS-CoV-2 Molecular Virology Medicinal Plants
ICAR 2025 Conference

ICAR 2025 — Las Vegas, USA

Professor El Kalamouni presenting at the 38th International Conference on Antiviral Research

Academic Journey

2007–2010
PhD in Chemistry
Université Paul Sabatier — Toulouse III, France
Doctoral research in organic chemistry and natural product synthesis.
2011
Associate Professor
University of La Réunion
Joined the faculty as Maître de Conférences, establishing his antiviral natural products research program at PIMIT Lab.
2018
Breakthrough Publications
Viruses · IJMS · Scientific Reports
Published landmark studies on Zika virus subversion of host antiviral defenses and flavonoid-based antiviral compounds.
2022
ICAR Young Investigator Award
International Society for Antiviral Research
Awarded 1st place at the 35th International Conference on Antiviral Research (ICAR 2022) for outstanding contributions to antiviral research.
2023–Present
Deputy Director, PIMIT Lab
UMR PIMIT — University of La Réunion
Appointed Deputy Director of the PIMIT research unit. Leads the Master 2 Biologie Santé program in Tropical Infectiology and Zoonoses.
2024–Present
Academic Editor
PLOS Neglected Tropical Diseases
Serves as Academic Editor for one of the world's leading journals on neglected tropical diseases.

Flagship Projects &
Research Focus

🦟
Arbovirus Research
Investigating the molecular mechanisms by which mosquito-borne viruses (Zika, Dengue, Ross River) infect and replicate in human cells.
🌿
Antiviral Natural Products
Systematic discovery of bioactive compounds from endemic Mascarene Island plants with antiviral properties using bio-guided fractionation.
🧬
Host-Pathogen Interactions
Elucidating how viruses subvert host cell defenses, including the Heme Oxygenase-1 pathway and ER stress responses.
💊
Drug Development
Translating natural product discoveries into drug candidates through structure-activity relationship studies and analogue synthesis.
012024–2028
CAZIKANO
Contemporary African Zika Virus

A flagship multi-institutional project investigating the replication properties and pathogenesis of contemporary African Zika virus strains. Addresses the urgent public health concern of Zika re-emergence in West Africa and aims to develop targeted antiviral strategies.

RolePIMIT Coordinator & Principal Investigator
Budget€3.25M total · €1.33M PIMIT
FundingANRS MIE France 2030
Zika VirusWest AfricaPathogenesisAntivirals
022023–2027
TRÉTZERBAJ
Tropical Plant-Based Antiviral Treatments

A multidisciplinary program linking Réunion Island's extraordinary biodiversity with infectious disease treatment. The Creole name reflects deep cultural roots. Aims to build an Extract Library of La Réunion and establish a high-throughput antiviral screening platform.

RoleScientific Manager
Budget€2.5M total · €1M PIMIT
FundingSGPI France 2030
BiodiversityMedicinal PlantsScreening Platform
032022–2024
CYCLOPE
Antiviral Cyclopeptides from Tropical Flora

Targeted isolation and pharmacological characterization of antiviral cyclopeptides from tropical plant species. In collaboration with ICSN (CNRS), developed hit-to-lead analogues with potent activity against Zika and Dengue viruses, resulting in patent WO2024231530.

RolePIMIT Coordinator & PI
Budget€603K total · €250K PIMIT
FundingSATT Paris-Saclay
CyclopeptidesDrug DiscoveryPatentDengue
Tropical research laboratory

Science at the Heart of the Indian Ocean

Based on Réunion Island, Professor El Kalamouni's laboratory benefits from unique access to the extraordinary biodiversity of the Mascarene Islands — a hotspot of endemic medicinal plants that serve as a natural library for antiviral drug discovery.

Scientific Output &
Key Contributions

70+
Total Publications
Peer-reviewed articles
1,146+
Citations
Google Scholar
56
HAL Documents
Open access
1
Patent Filed
WO2024231530

Science in Service of
Society & Community

Beyond the laboratory, Professor El Kalamouni is committed to education, international collaboration, and ensuring that scientific discoveries benefit the communities most affected by tropical infectious diseases.

📚
Education
Master 2 Program Director

Leads the Master 2 Biologie Santé — Parcours Infectiologie Tropicale et Zoonoses at the University of La Réunion, training the next generation of tropical health scientists.

→ Shaping Future Scientists
📰
Editorial
Academic Editor, PLOS NTDs

Serves as Academic Editor for PLOS Neglected Tropical Diseases, one of the world's leading open-access journals dedicated to diseases affecting the world's poorest populations.

→ Global Scientific Governance
🌍
International
ICAR Conference Participant

Regular contributor to the International Conference on Antiviral Research (ICAR), presenting PIMIT's advances on natural product-based strategies against emerging viruses.

→ Global Scientific Exchange
🤝
Collaboration
International Research Networks

Leads collaborative research with institutions across France, Australia, Malaysia, Madagascar, Mauritius, Lithuania, and Vietnam — building bridges between tropical regions facing shared viral threats.

→ Cross-Continental Partnerships
🏝️
Local Impact
Réunion Island Biodiversity Champion

Through TRÉTZERBAJ, works directly with local economic actors, traditional medicine practitioners, and territorial development agencies to valorize Réunion's endemic medicinal plant heritage.

→ Territorial Development
🔬
Innovation
Patent & Technology Transfer

Co-inventor of a patent for novel antiviral cyclopeptides (WO2024231530), demonstrating the translational impact of fundamental research into potential therapeutic applications.

→ Science to Society
ICAR 2025

ICAR 2025 — Las Vegas, USA

Professor El Kalamouni presenting at the 38th International Conference on Antiviral Research
International Conferences
2025
ICAR 38th
Las Vegas, USA
Natural product strategies against Zika & SARS-CoV
2024
ICAR 37th
International
Contemporary African Zika virus research
2023
BIONATURAL 2023
Lisbon, Portugal
Bio-guided fractionation of Réunion flora
2022
ICAR 35th
Seattle, USA
Young Investigator Award — 1st Place
2024
Natural Substances Workshop
Kuala Lumpur, Malaysia
International collaboration on antiviral natural products
"Establishment of different antiviral approaches using phytochemistry against emerging arboviruses."

— Professor Chaker El Kalamouni, Research Mission Statement

Get in Touch

Institutional Contact
📞
Phone
+262 2 62 93 88 22
📍
Address
UMR PIMIT
Université de La Réunion
Saint-Denis, La Réunion, France
🏛
Affiliation
UMR PIMIT (INSERM U1187 · CNRS 9192 · IRD 249)
University of La Réunion